Tag Archives: entropy

Jonah Lehrer reports on trouble in science (again)

There is a new blog entry by Jonah Lehrer, “How Does Prozac Work?” (Nov 17, find it here) that touches on the decline effect in pharmaceuticals. It’s not good news. And in a strange way it is stressing me out personally.
First Lehrer discusses the failure of a promising new anti-depressant drug, designated GSK372475, from Glaxo.

The progress of this blog so far . . .

. . . has been an illustration of the maximum entropy principle. First there  was a single post. Then was a long stretch of time (several months) with very little activity. I logged in from time to time but did little more than sigh and say, “Not right now.”
But at last, in the past ten

Blog Launch

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elcome to The Decline Effect Blog!
This blog is about applications of the maximum entropy principle, developed starting in 1957 by Edwin Jaynes. The MEP has an extraordinarily wide range of application — much wider even than most writers in the field realize.
Initially the blog will focus on two items. One is my forthcoming book, The